She also has a rivalry with Leonardo, Tiger Claw, April O'Neil (formerly), Oroku Saki/ The Shredder/ Super Shredder/ Undead Shredder, Hattori Tatsu, and The Shredder (1987). She wields a Shikomizue sword as her signature weapon of choice. With this and Tiger Claw leaving The Foot after the resurrection of Undead Shredder and Kavaxas betraying him, lead to the Kunoichi to lead The Foot Clan as her own. Oroku Saki, who mutated himself into Super Shredder and assassinated her father, was later on assassinated by Leonardo. After she was captured and brainwashed with Parasites by Saki, she looses control of the worm and recruits Shinigami (an old friend from Japan) to start the rebellion and war against The Foot.
But when she learned about her true origins, she rebels against The Foot and eventually gets mutated into a mutant white horned viper accidentally. Once The Shredder tracked down Splinter in New York City, she accompanies the clan to help her "father" with his vengeance. Saki raised her as his own daughter after assassinating Tang Shen, which leads to her being renamed, being trained into Ninjutsu as a Kunoichi, and becomes the second-in-command of The Foot Clan. As the only daughter of Hamato Yoshi and Tang Shen, who was born and raised in Tokyo, Japan with her family clan, The Hamato Clan, she was taken away from her parents by Oroku Saki. Hamato Miwa, aka Oroku Karai, or Serpent Karai, is an ally of the Ninja Turtles. Karai's introduction to Leonardo, New Girl in Town Second-In-Command Of The Foot Clan (Formerly) Hamato Miwa between her mutant and human form.